Article
TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes.
Metabolism: clinical and experimental - 1 Aug 2022
Verma Manu, Loh Nellie Y, Sabaratnam Rugivan, Vasan Senthil K, van Dam Andrea D, Todorčević Marijana, Neville Matthew J, Toledo Enrique, Karpe Fredrik, Christodoulides Constantinos
Abstract excerpt
INTRODUCTION: Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo studies in transgenic mice have highlighted important roles for TCF7L2 in adipose tissue biology and systemic metabolism. OBJECTIVE: To map the expression of TCF7L2 in...
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