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Article

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.

Genome research - 1 Sept 2011

Savic Daniel, Ye Honggang, Aneas Ivy, Park Soo-Young, Bell Graeme I, Nobrega Marcelo A

Abstract excerpt

Genome-wide association studies (GWAS) have consistently implicated noncoding variation within the TCF7L2 locus with type 2 diabetes (T2D) risk. While this locus represents the strongest genetic determinant for T2D risk in humans, it remains unclear how these noncoding variants affect disease etiology. To test the hypothesis that the T2D-associated interval harbors cis-regulatory elements controlling TCF7L2...

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Share to Blood Glucose
Share to Chromosomes, Artificial, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Enhancer Elements, Genetic

Share to Gene Order

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Share to Metabolic Networks and Pathways

Share to Transcription Factor 7-Like 2 Protein

Source

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Identifiers

PMID: 21673050
DOI: 10.1101/gr.123745.111
PMCID: PMC3166827

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