Article
Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
Diabetes - 1 Oct 2006
Cauchi Stéphane, Meyre David, Dina Christian, Choquet Hélène, Samson Chantal, Gallina Sophie, Balkau Beverley, Charpentier Guillaume, Pattou François, Stetsyuk Volodymyr, Scharfmann Raphaël, Staels Bart, Frühbeck Gema, Froguel Philippe
Abstract excerpt
Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2 diabetes in subjects of European origin in the DeCode study. We genotyped the two most associated variants (rs7903146 and rs12255372) in 2,367 French type 2 diabetic subjects and in 2,499 control subjects. Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an...
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