Article
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
Diabetes - 1 Sept 2006
Groves Christopher J, Zeggini Eleftheria, Minton Jayne, Frayling Timothy M, Weedon Michael N, Rayner Nigel W, Hitman Graham A, Walker Mark, Wiltshire Steven, Hattersley Andrew T, McCarthy Mark I
Abstract excerpt
Recent data suggest that common variation in the transcription factor 7-like 2 (TCF7L2) gene is associated with type 2 diabetes. Evaluation of such associations in independent samples provides necessary replication and a robust assessment of effect size. Using four TCF7L2 single nucleotide polymorphisms (SNPs; including the two most associated in the previous study), we conducted a case-control study in 2,158...
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