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Molecular Signatures of Dengue Virus-Specific IL-10/IFN-γ Co-producing CD4 T Cells and Their Association with Dengue Disease

1 Dec 2019

Abstract excerpt

Dengue virus (DENV) can cause diseases ranging from dengue fever (DF) to more severe dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Whether antiviral T cells contribute to the protection against or pathogenesis of severe disease is not well defined. Here, we identified antigen-specific IL-10 + IFN-γ + double-positive (DP) CD4 T cells during acute DENV infection. While the transcriptomic signatures of...

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Identifiers

PMID: 31875555
DOI: 10.1016/j.celrep.2019.11.098

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