Article

Clusterin regulates microglial inflammation and cognitive function independent of amyloid pathology in Alzheimer’s disease

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Clusterin (CLU) is a major genetic risk factor for late-onset Alzheimer’s disease (AD), yet the mechanism underlying this risk remains unclear. This study investigated the role of CLU in regulating microglial inflammation, amyloid pathology, and cognitive function in CLU-deficient and AD models. CLU synthesis and secretion in microglia were highly dynamic, with minimal expression at rest but mar...

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Literature Corpus work: 1a664ea3-0df0-58cb-aff4-52c485cd2d69
DOI: 10.64898/2026.07.30.741791

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