Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

28 Feb 2019

Abstract excerpt

Clusterin (CLU) or APOJ is a multifunctional glycoprotein which has been implicated in several physiological and pathological states, including Alzheimer’s disease (AD). With a prominent extracellular chaperone function, additional roles have been discussed for clusterin, including lipid transport and immune modulation, and it is involved in pathways common to several diseases such as cell death and survival,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Clusterin in disease pathology
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30872998
DOI: 10.3389/fnins.2019.00164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other PathologiesPMID 30872998Read ↗

The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and TherapySemantic proximity Read ↗

Clusterin as a Potential Biomarker of Obesity-Related Alzheimer’s Disease RiskSemantic proximity Read ↗

Pathways to Alzheimer’s Disease: The Intersecting Roles of Clusterin and Apolipoprotein E in Amyloid-β Regulation and Neuronal HealthSemantic proximity Read ↗

Clusterin in Alzheimer’s disease: a player in the biological behavior of amyloid-betaSemantic proximity Read ↗

Clusterin levels are increased in <scp>A</scp>lzheimer's disease and influence the regional distribution of A<b>β</b>Semantic proximity Read ↗

Glycosylated clusterin species facilitate Aβ toxicity in human neuronsSemantic proximity Read ↗

Brain clusterin protein isoforms and mitochondrial localizationSemantic proximity Read ↗

Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's DiseaseSemantic proximity Read ↗

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutationsSemantic proximity Read ↗

The Emerging Role of the Molecular Chaperone Clusterin in Parkinson’s DiseaseSemantic proximity Read ↗

Clusterin is a Potential Therapeutic Target in Alzheimer’s DiseaseSemantic proximity Read ↗

Genetics of clusterin isoform expression and Alzheimer's disease risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.