Article

Multimodal analysis identifies pericyte-centered signaling programs altered by sex and brain region in Alzheimer’s Disease

2025-08-09

Abstract excerpt

Pericytes are critical components of the neurovascular unit (NVU), regulating endothelial cell (EC) stability, blood-brain barrier (BBB) integrity, and neuroimmune signaling. However, their role in Alzheimer’s Disease (AD), particularly in the context of sex differences and brain region specificity, remains poorly defined. Here, we use single-nucleus RNA sequencing (snRNA-seq) to characterize transcriptional and i...

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Literature Corpus work: c716ff5e-6b41-5c35-9f7d-df5b669d34d9
DOI: 10.1101/2025.08.06.668915

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Multimodal analysis identifies pericyte-centered signaling programs altered by sex and brain region in Alzheimer’s DiseaseDOI 10.1101/2025.08.06.668915Read

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