Article

HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species

2025-08-24

Abstract excerpt

The physiological properties of human and rodent neurons differ, yet the extent to which these differences reflect human specializations is often unclear. Compared with their rodent counterparts, human supragranular pyramidal neurons possess enriched HCN-channel-dependent intrinsic membrane properties and a related sensitivity to synaptic inputs containing delta/theta band frequencies. We tested whether other prim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b48769be-7523-562b-bbda-03353c375fdf
DOI: 10.1101/2025.08.22.671856

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate speciesDOI 10.1101/2025.08.22.671856Read

h-channels contribute to divergent electrophysiological properties of supragranular pyramidal neurons in human versus mouse cerebral cortexSemantic proximity Read

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal ProfilingSemantic proximity Read

Transcriptome-Inspired Spiking Simulations Uncover Human-Specific Prefrontal Dynamics and Provide a Mechanistic Platform for Species-Appropriate Disease ModelingSemantic proximity Read

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neuronsSemantic proximity Read

Hyperpolarization-activated cation channels shape the spiking frequency preference of human cortical layer 5 pyramidal neuronsSemantic proximity Read

Signature morpho-electric, transcriptomic, and dendritic properties of extratelencephalic-projecting human layer 5 neocortical pyramidal neuronsSemantic proximity Read

Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortexSemantic proximity Read

Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell typeSemantic proximity Read

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortexSemantic proximity Read

Hyperpolarization-activated cation channel mediated intrinsic plasticity changes underlie the malleability of within cell-type electrophysiological heterogeneitySemantic proximity Read

Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate StriatumSemantic proximity Read

Cellular and Synaptic Diversity of Layer 2-3 Pyramidal Neurons in Human IndividualsSemantic proximity Read