Article

Neurophysiological consequences of synapse loss in progressive supranuclear palsy

2022-06-23

Abstract excerpt

Synaptic loss occurs early in many neurodegenerative diseases and contributes to cognitive impairment even in the absence of gross atrophy. Currently, for human disease there are few formal models to explain how cortical networks underlying cognition are affected by synaptic loss. We advocate that biophysical models of neurophysiology offer both a bridge from clinical to preclinical models of pathology, and quanti...

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Literature Corpus work: c2a7fd39-404a-51af-bfdd-f4fa7169cc05
DOI: 10.1101/2022.06.22.22276697

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