Article

Aβ/APP-induced hyperexcitability and dysregulation of homeostatic synaptic plasticity in models of Alzheimer’s disease

2022-01-25

Abstract excerpt

The proper function of the nervous system is dependent on the appropriate timing of neuronal firing. Synapses continually undergo rapid activity-dependent modifications that require feedback mechanisms to maintain network activity within a window in which communication is energy efficient and meaningful. Homeostatic synaptic plasticity (HSP) and homeostatic intrinsic plasticity (HIP) are such negative feedback mec...

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Literature Corpus work: 7b6ba9b0-ed24-56c7-be56-e25b12b18969
DOI: 10.1101/2022.01.25.477711

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