Article

Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance

2024-07-02

Abstract excerpt

Resistance to cancer therapy is driven by both cell-intrinsic and microenvironmental factors. Previous work has revealed that multiple resistant cell fates emerge in melanoma following treatment with targeted therapy and that, in vitro, these resistant fates are determined by the transcriptional state of individual cells prior to exposure to treatment. What remains unclear is whether these resistant fates are shar...

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Literature Corpus work: e6e59d49-61e8-5597-af30-dc7be58558de
DOI: 10.1101/2024.06.30.601416

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