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Article

Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response.

Cell reports - 25 Jul 2023

Randic Tijana, Magni Stefano, Philippidou Demetra, Margue Christiane, Grzyb Kamil, Preis Jasmin Renate, Wroblewska Joanna Patrycja, Nazarov Petr V, Mittelbronn Michel, Frauenknecht Katrin B M, Skupin Alexander, Kreis Stephanie

Abstract excerpt

Treatment options for patients with NRAS-mutant melanoma are limited and lack an efficient targeted drug combination that significantly increases overall and progression-free survival. In addition, targeted therapy success is hampered by the inevitable emergence of drug resistance. A thorough understanding of the molecular processes driving cancer cells' escape mechanisms is crucial to tailor more efficient...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

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Share to Proto-Oncogene Proteins B-raf

Share to Receptors, Purinergic P2X7

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Source

Identifiers

PMID: 37379213
DOI: 10.1016/j.celrep.2023.112696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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