Article

Nongenetic Mechanisms of Drug Resistance in Melanoma

2019-11-25

Abstract excerpt

Resistance to targeted and immune-based therapies limits cures in patients with metastatic melanoma. A growing number of reports have identified nongenetic primary resistance mechanisms including intrinsic microenvironment- and lineage plasticity–mediated processes serving critical functions in the persistence of disease throughout therapy. There is a temporally shifting spectrum of cellular identities fluidly occ...

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Literature Corpus work: a4deedb0-ced4-5298-92c5-aa551ef8783c
DOI: 10.1146/annurev-cancerbio-030419-033533

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