Article
Genomic characteristics and prognosis of lung cancer patients with MSI-H: A cohort study.
Lung cancer (Amsterdam, Netherlands) - 1 Jul 2023
Tian Jie, Wang Hongdan, Lu Conghua, Liu Lan, Zhang Xianquan, Xie Yunbo, Li Rutian, Lv Xin, Fu Dan, Zhang Ling, Fang Xisheng, Wang Xuming, Hu Jing, Liu Xinyi, Huang Xiaochun, Zhao Qian, Luo Nuo, Tang Huan, Zhong Zhaoyang, He Yong, Li Li
Abstract excerpt
BACKGROUND: Microsatellite instability (MSI) is the first pan-cancer biomarker approved to guide immune checkpoint inhibitor therapy for MSI-high (MSI-H) solid tumors. In lung cancer, the MSI-H frequency is very low, and the genetic characteristics and prognosis of lung cancer with MSI-H were rarely reported. METHODS: Next-generation sequencing and immunohistochemistry were used detect MSI status, tumor mutation...
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