Article

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

2022-07-25

Abstract excerpt

<title>Abstract</title> <p>KRAS is one of the most frequently mutated oncogenes in lung cancer. To identify novel KRAS-specific vulnerabilities, we performed RNAi screens in spheroid cultures of primary tumor cells derived from a mouse model of lung cancer driven by activation of Kras and loss of p53. Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1), an epigenetic regulator involved in DNA methylat...

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Literature Corpus work: a286e0f7-00ce-58fb-8bcf-17abd7e035d6
DOI: 10.21203/rs.3.rs-1651106/v1

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