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Article

EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.

Cell - 6 Jan 2022

Marzio Antonio, Kurz Emma, Sahni Jennifer M, Di Feo Giuseppe, Puccini Joseph, Jiang Shaowen, Hirsch Carolina Alcantara, Arbini Arnaldo A, Wu Warren L, Pass Harvey I, Bar-Sagi Dafna, Papagiannakopoulos Thales, Pagano Michele

Abstract excerpt

Non-small cell lung cancers (NSCLCs) harboring KEAP1 mutations are often resistant to immunotherapy. Here, we show that KEAP1 targets EMSY for ubiquitin-mediated degradation to regulate homologous recombination repair (HRR) and anti-tumor immunity. Loss of KEAP1 in NSCLC induces stabilization of EMSY, producing a BRCAness phenotype, i.e., HRR defects and sensitivity to PARP inhibitors. Defective HRR contributes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34963055
DOI: 10.1016/j.cell.2021.12.005
PMCID: PMC8751279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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