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SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer

12 Oct 2021

Abstract excerpt

Although the DNA damage response (DDR) is associated with the radioresistance characteristics of lung cancer cells, the specific regulators and underlying mechanisms of the DDR are unclear. Here, we identified the serine proteinase inhibitor clade E member 2 (SERPINE2) as a modulator of radiosensitivity and the DDR in lung cancer. Cells exhibiting radioresistance after ionizing radiation show upregulation of...

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PMID: 34648881
DOI: 10.1016/j.canlet.2021.10.001

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