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Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer.

Cancer research - 15 Jun 2021

Chang Antao, Liu Liang, Ashby Justin M, Wu Dan, Chen Yanan, O'Neill Stacey S, Huang Shan, Wang Juan, Wang Guanwen, Cheng Dongmei, Tan Xiaoming, Petty W J, Pasche Boris C, Xiang Rong, Zhang Wei, Sun Peiqing

Abstract excerpt

When recruited to promoters, histone 3 lysine 4 (H3K4) methyltransferases KMT2 (KMT2A-D) activate transcription by opening chromatin through H3K4 methylation. Here, we report that KMT2 mutations occur frequently in non-small cell lung cancer (NSCLC) and are associated with high mutation loads and poor survival. KMT2C regulated DNA damage responses (DDR) through direct recruitment to DNA damage sites by Ago2 and...

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Identifiers

PMID: 33853832
DOI: 10.1158/0008-5472.CAN-21-0688
PMCID: PMC8260460

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