Article

Intestinal Transgene Delivery with Native <i>E. coli</i> Chassis Allows Persistent Physiological Changes

2021-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Live bacterial therapeutics (LBT) could reverse disease by engrafting in the gut and providing persistent beneficial functions in the host. However, attempts to functionally manipulate the gut microbiome of conventionally-raised (CR) hosts have been unsuccessful, because engineered microbial organisms (i.e., chassis) cannot colonize the hostile luminal environment. In this proof-of-concept study...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1990c1c6-3817-5d4a-8d64-8d447b7c5ae7
DOI: 10.1101/2021.11.11.468006

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intestinal Transgene Delivery with Native <i>E. coli</i> Chassis Allows Persistent Physiological ChangesDOI 10.1101/2021.11.11.468006Read

A durably colonizing engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitisSemantic proximity Read

<i>In situ</i> deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic <i>E. coli</i>Semantic proximity Read

<i>In situ</i> targeted mutagenesis of gut bacteriaSemantic proximity Read

Genetic Engineering of Resident Bacteria in the Gut MicrobiomeSemantic proximity Read

Decoding <i>E. coli</i> ’s Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and StrainsSemantic proximity Read

Colibactin-producing <i>E. coli</i> promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiationSemantic proximity Read

Controlled colonization of the human gut with a genetically engineered microbial therapeuticSemantic proximity Read

Genetically engineered bacteria as inflammatory bowel disease therapeuticsSemantic proximity Read

Controlled colonization of the human gut with a genetically engineered microbial medicineSemantic proximity Read

Bio-engineering a common probiotic to exploit colonic inflammation promotes reliable efficacy in translational models of colitisSemantic proximity Read

Effects in the use of a genetically engineered strain of<i>Lactococcus lactis</i>delivering in situ IL-10 as a therapy to treat low-grade colon inflammationSemantic proximity Read

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistanceSemantic proximity Read