Article

Decoding <i>E. coli</i> ’s Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and Strains

2026-01-05

Abstract excerpt

Escherichia coli , a ubiquitous member of the mammalian gut microbiota, exhibits remarkable genetic diversity underpinning its commensal or pathogenic lifestyles. Deciphering the precise genetic determinants enabling E. coli ’s adaptation within the complex and dynamic intestinal environment is critical for understanding host-microbe symbiosis and enteric disease pathogenesis. Here, we establish an in vivo CRISP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9dddc380-0128-59bb-be7f-07c7d74bc901
DOI: 10.64898/2026.01.05.697630

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding <i>E. coli</i> ’s Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and StrainsDOI 10.64898/2026.01.05.697630Read

Mobile-CRISPRi: Enabling Genetic Analysis of Diverse BacteriaSemantic proximity Read

Genome-scale CRISPRi profiling reveals metabolic vulnerabilities of uropathogenic <i>Escherichia coli</i> in human urineSemantic proximity Read

Gut Microbiology in the Age of CRISPR, AI, and Omics: A ReviewSemantic proximity Read

<i>Escherichia coli</i> strains from patients with inflammatory bowel diseases have disease-specific genomic adaptationsSemantic proximity Read

Evolution of <i>E. coli</i> in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevanceSemantic proximity Read

Oxalyl-CoA decarboxylase is a major and specific virulence factor for Adherent Invasive Escherichia coliSemantic proximity Read

Long-read sequencing to interrogate strain-level variation among adherent-invasive <i>Escherichia coli</i> isolated from human intestinal tissueSemantic proximity Read

Dietary emulsifiers and host inflammation synergistically drive genomic evolution of Crohn’s disease-associated <i>E. coli</i> toward enhanced pathogenicitySemantic proximity Read

Biochemical traits that <i>Escherichia coli</i> evolved during its adaption to the gastrointestinal tract of humansSemantic proximity Read

Functional and genetic adaptations contributing to <i>Enterococcus faecalis</i> persistence in the female urinary tractSemantic proximity Read

Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversarySemantic proximity Read

Hidden Diversity in <i>Enterococcus faecalis</i> Revealed by CRISPR2 Screening: Eco-evolutionary Insights into a Novel SubspeciesSemantic proximity Read