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<i>In situ</i> deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic <i>E. coli</i>

2024-07-30

Abstract excerpt

Engineered smart microbes that deliver therapeutic payloads are emerging as treatment modalities, particularly for diseases with links to the gastrointestinal tract. Enterohemorrhagic E coli (EHEC) is a causative agent of potentially lethal hemolytic uremic syndrome. Given concerns that antibiotic treatment increases EHEC production of Shiga toxin (Stx), which is responsible for systemic disease, novel remedies a...

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Literature Corpus work
727ac7da-a254-50fa-ba6d-c1fed6343c3f
DOI
10.1101/2024.07.30.605899
Open publication

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