Article

Colibactin-producing <i>E. coli</i> promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiation

2025-11-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Gastroesophageal adenocarcinoma (GEAC) is a malignancy of the gastroesophageal junction (GEJ) and is associated with reflux of gastroduodenal contents and Barrett’s Esophagus (BE). A shift towards gram-negative bacteria in the microbiota of the GEJ additionally promotes inflammation and likely carcinogenesis. Enterobacteriaceae are enriched in advanced stages of GEAC...

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Literature Corpus work: a95e2e23-9533-594a-bde2-41a52e4138ed
DOI: 10.1101/2025.11.10.687579

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