Article

A durably colonizing engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic molecules, but their efficacy is limited by inefficient colonisation, safety concerns and the need for repeated administration or auxiliary delivery systems. <h4>Objective</h4> To develop a safety-optimised native bacterial chassis capable of long-term gut colon...

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Literature Corpus work: 0e37a08f-aec9-53d8-a894-70ee37d45718
DOI: 10.64898/2026.08.02.741375

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