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Controlled colonization of the human gut with a genetically engineered microbial therapeutic

17 Jul 2025

Abstract excerpt

Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft engineered bacteria into diverse microbiota in mice by using a porphyran prebiotic. Building on this approach, we have now engineered conditional attenuation into a porphyran-utilizing strain of Phocaeicola vulgatus...

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PMID: 40674481
DOI: 10.1126/science.adu8000

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