Article

Controlled colonization of the human gut with a genetically engineered microbial medicine

2024-10-04

Abstract excerpt

Precision microbiome programming for therapeutic applications has been limited by challenges in achieving reproducible colonization of the colon. Previously, we used a porphyran prebiotic to create a synthetic niche to engraft engineered bacteria into diverse microbiota in mice. Here we extend that work with biocontainment that links essential gene expression to porphyran presence yielding a platform for controlle...

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Literature Corpus work: a8c44ef6-73f0-54b0-a310-8a192222d4dd
DOI: 10.1101/2024.10.03.24314621

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