Article

Tip60 protects against amyloid-β peptide-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegenerative progression

2020-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is an age-related neurodegenerative disorder hallmarked by amyloid-β (Aβ) plaque accumulation, neuronal cell death, and cognitive deficits that worsen during disease progression. Histone acetylation dysregulation, caused by an imbalance between reduced histone acetyltransferases (HAT) Tip60 and increased histone deacetylase 2 (HDAC2) levels, can directly contribute to AD...

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Literature Corpus work: 195de1a9-653d-5b5c-a999-d7cb872865a8
DOI: 10.1101/2020.06.09.142885

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