Article

Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) causes amyloid formation, neuritic dystrophy, gliosis, synapse loss, behavioral abnormalities, and weight loss. 5xFAD transgenic mice simulate these alterations. To further investigate overall tau reduction as a therapeutic strategy for AD-related abnormalities, we compared 5xFAD mice carrying 2, 1, or 0 Mapt alleles encoding endogenous wildtype tau. Behavioral alterati...

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Literature Corpus work: e91a0e9e-8871-54f3-b08a-fabb6d351568
DOI: 10.64898/2026.08.03.741071

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