Article

Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer’s Disease fly models

2024-03-13

Abstract excerpt

Peripheral tissues become disrupted in Alzheimer’s Disease (AD). However, a comprehensive understanding of how the expression of AD-associated toxic proteins, Aβ42 and Tau, in neurons impacts the periphery is lacking. Using Drosophila , a prime model organism for studying aging and neurodegeneration, we generated the Alzheimer’s Disease Fly Cell Atlas (AD-FCA): whole-organism single-nucleus transcriptomes of 219...

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Literature Corpus work: 01c82103-b180-5938-bff7-0126c8267fd0
DOI: 10.1101/2024.03.10.584317

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