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Article

Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Apr 2013

Johnson Ashley A, Sarthi Jessica, Pirooznia Sheila K, Reube William, Elefant Felice

Abstract excerpt

Axonal transport defects and axonopathy are prominent in early preclinical stages of Alzheimer's disease (AD), often preceding known disease-related pathology by over a year. As epigenetic transcriptional regulatory mechanisms, such as histone acetylation, are critical for neurogenesis, it is pos...

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Identifiers

PMID: 23616558
DOI: 10.1523/JNEUROSCI.3739-12.2013
PMCID: PMC3711104

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23616558-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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