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Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain

2021-02-27

Abstract excerpt

<h4>ABSTRACT</h4> Disruption of histone acetylation mediated gene control is a critical step in Alzheimer’s Disease (AD), yet chromatin analysis of antagonistic histone acetyltransferases (HATs) and histone deacetylases (HDACs) causing these alterations remains uncharacterized. We report the first Tip60 HAT versus HDAC2 chromatin and transcriptional profiling study in Drosophila brains that model early human AD....

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Literature Corpus work
f1dcc303-8c81-5070-b6e2-f8448dadf8af
DOI
10.1101/2021.02.27.433179
Open publication

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Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brainDOI 10.1101/2021.02.27.433179
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