Article
Integrated analysis of the aging brain transcriptome and proteome in tauopathy.
Molecular neurodegeneration - 29 Sept 2020
Mangleburg Carl Grant, Wu Timothy, Yalamanchili Hari K, Guo Caiwei, Hsieh Yi-Chen, Duong Duc M, Dammer Eric B, De Jager Philip L, Seyfried Nicholas T, Liu Zhandong, Shulman Joshua M
Abstract excerpt
BACKGROUND: Tau neurofibrillary tangle pathology characterizes Alzheimer's disease and other neurodegenerative tauopathies. Brain gene expression profiles can reveal mechanisms; however, few studies have systematically examined both the transcriptome and proteome or differentiated Tau- versus age-dependent changes. METHODS: Paired, longitudinal RNA-sequencing and mass-spectrometry were performed in a Drosophila...
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