Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm

Abstract excerpt

Abstract The reaction of CO 2 with H 2 O to form bicarbonate (HCO 3 − ) and H + controls sperm motility and fertilization via HCO 3 − -stimulated cAMP synthesis. A complex network of signaling proteins participates in this reaction. Here, we identify key players that regulate intracellular pH (pH i ) and HCO 3 − in human sperm by quantitative mass spectrometry (MS) and kinetic patch-clamp fluorometry. The resting...

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