Article
Chimeric evidence for a role of the connexin cytoplasmic loop in gap junction channel gating.
Pflugers Archiv : European journal of physiology - 1 Apr 1996
Wang X, Li L, Peracchia L L, Peracchia C
Abstract excerpt
Gap junction channels are regulated by gates that close upon exposure to 100% CO2, probably via an increase in intracellular Ca2+ concentration, [Ca2+]i. For defining connexin (Cx) domain(s) involved in gating, we have studied chemical and voltage gating sensitivities of channels made of Cx38, Cx32 or chimeras of the above, expressed in Xenopus oocytes. Cx38 channels are more sensitive to CO2 and voltage than...
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