Article
Is the chemical gate of connexins voltage sensitive? Behavior of Cx32 wild-type and mutant channels.
The American journal of physiology - 1 Jun 1999
Peracchia C, Wang X G, Peracchia L L
Abstract excerpt
Connexin channels are gated by transjunctional voltage (Vj) or CO2 via distinct mechanisms. The cytoplasmic loop (CL) and arginines of a COOH-terminal domain (CT1) of connexin32 (Cx32) were shown to determine CO2 sensitivity, and a gating mechanism involving CL-CT1 association-dissociation was proposed. This study reports that Cx32 mutants, tandem, 5R/E, and 5R/N, designed to weaken CL-CT1 interactions, display...
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