Article
Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2007
Oshima Atsunori, Tani Kazutoshi, Hiroaki Yoko, Fujiyoshi Yoshinori, Sosinsky Gina E
Abstract excerpt
Connexin molecules form intercellular membrane channels facilitating electronic coupling and the passage of small molecules between adjoining cells. Connexin26 (Cx26) is the second smallest member of the gap junction protein family, and mutations in Cx26 cause certain hereditary human diseases such as skin disorders and hearing loss. Here, we report the electron crystallographic structure of a human Cx26 mutant...
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