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Cell-to-cell signalling mediated via CO <sub>2</sub> : activity dependent axonal CO <sub>2</sub> production opens Cx32 in the Schwann cell paranode

2025-04-05

Abstract excerpt

Loss of function mutations of Cx32, which is expressed in Schwann cells, cause X-linked Charcot Marie Tooth disease, a slowly progressive peripheral neuropathy. Cx32 is thus essential for the maintenance of myelin. During action potential propagation, Cx32 hemichannels in the Schwann cell paranode are thought to open and release ATP. As Cx32 hemichannels are directly sensitive to CO 2 , we have tested whether CO...

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Literature Corpus work
643c0f92-a9e1-5675-b0fd-810bc085d3a1
DOI
10.1101/2025.04.04.647196
Open publication

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Cell-to-cell signalling mediated via CO <sub>2</sub> : activity dependent axonal CO <sub>2</sub> production opens Cx32 in the Schwann cell paranodeDOI 10.1101/2025.04.04.647196
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