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Article

Rational design of new NO and redox sensitivity into connexin26 hemichannels.

Open biology - 1 Feb 2015

Meigh Louise, Cook Daniel, Zhang Jie, Dale Nicholas

Abstract excerpt

CO2 directly opens hemichannels of connexin26 (Cx26) by carbamylating K125, thereby allowing salt bridge formation with R104 of the neighbouring subunit in the connexin hexamer. The formation of the inter-subunit carbamate bridges within the hexameric hemichannel traps it in the open state. Here, we use insights derived from this model to test whether the range of agonists capable of opening Cx26 can be extended...

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Identifiers

PMID: 25673329
DOI: 10.1098/rsob.140208
PMCID: PMC4345282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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