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Article

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2.

eLife - 3 Jun 2024

Brotherton Deborah H, Nijjar Sarbjit, Savva Christos G, Dale Nicholas, Cameron Alexander David

Abstract excerpt

Connexins allow intercellular communication by forming gap junction channels (GJCs) between juxtaposed cells. Connexin26 (Cx26) can be regulated directly by CO2. This is proposed to be mediated through carbamylation of K125. We show that mutating K125 to glutamate, mimicking the negative charge of carbamylation, causes Cx26 GJCs to be constitutively closed. Through cryo-EM we observe that the K125E mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38829031
DOI: 10.7554/eLife.93686
PMCID: PMC11147507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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