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Article

Zebrafish and mouse TASK-2 K(+) channels are inhibited by increased CO2 and intracellular acidification.

Pflugers Archiv : European journal of physiology - 1 Jul 2014

Peña-Münzenmayer Gaspar, Niemeyer María Isabel, Sepúlveda Francisco V, Cid L Pablo

Abstract excerpt

TASK-2 is a K2P K(+) channel considered as a candidate to mediate CO2 sensing in central chemosensory neurons in mouse. Neuroepithelial cells in zebrafish gills sense CO2 levels through an unidentified K2P K(+) channel. We have now obtained zfTASK-2 from zebrafish gill tissue that is 49 % identical to mTASK-2. Like its mouse equivalent, it is gated both by extra- and intracellular pH being activated by...

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PMID: 24081451
DOI: 10.1007/s00424-013-1365-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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