Article

Multi-input drug-controlled switches of mammalian gene expression based on engineered nuclear hormone receptors

2023-02-01

Abstract excerpt

Protein-based switches that respond to different inputs to regulate cellular outputs, such as gene expression, are central to synthetic biology. For increased controllability, multi-input switches that integrate several cooperating and competing signals for the regulation of a shared output are of particular interest. The nuclear hormone receptor (NHR) superfamily offers promising starting points for engineering m...

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Literature Corpus work: 1902a95b-f5c1-5a02-85d4-bc351f28b776
DOI: 10.1101/2023.02.01.526549

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