Article

TuNR: Orthogonal Control of Mean and Variability of Endogenous Genes in a Human Cell Line

2020-05-24

Abstract excerpt

Stochastic fluctuations at the transcriptional level contribute to isogenic cell-to-cell heterogeneity in mammalian cell populations. However, we still have no clear understanding of the repercussions of this heterogeneity, given the lack of tools to independently control mean expression and variability of a gene. Here, we engineered a synthetic circuit to independently modulate mean expression and heterogeneity o...

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Identifiers and source

Literature Corpus work: 73b9ade7-413f-54cb-bfe9-a177f03250c6
DOI: 10.1101/2020.05.23.112979

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