Article

Synthetic Cytosolic Splicing Enables Programmable mRNA-Encoded Receptors

2025-04-27

Abstract excerpt

A typical cell therapy product comprises engineered cells that detect disease-related molecular cues in their surrounding or on a surface of a target cell, and activate a response that alleviates disease symptoms or eradicates diseased cells. mRNA as a therapeutic substrate has become prevalent in the last decade across multiple therapeutic areas, and it has also been evaluated as a building block of cell therapie...

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Literature Corpus work: 4ac64a84-3532-53da-a112-9325b7e0d689
DOI: 10.1101/2025.04.27.650769

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