Article

Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways

2025-03-20

Abstract excerpt

<h4>Background</h4> Engineered cells provide versatile tools for precise, tunable drug delivery, especially when synthetic stimulus-responsive gene circuits are incorporated. In many complex disease conditions, endogenous pathologic signals such as inflammation can vary dynamically over different time scales. For example, in autoimmune conditions such as rheumatoid arthritis or juvenile idiopathic arthritis, loca...

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Literature Corpus work: bd4aa7b5-1317-5308-9f77-f22f46775d5d
DOI: 10.1101/2025.03.20.644403

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