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G Protein–Coupled Receptors Revisited: Therapeutic Applications Inspired by Synthetic Biology

25 Oct 2013

Abstract excerpt

G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to hormones and neurotransmitters within the human body. They have much potential in the emerging field of synthetic biology, which is the rational, systematic design of biological systems with desired functionality. The responsiveness of GPCRs to a plethora of endogenous and exogenous ligands and stimuli make them ideal sensory...

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PMID: 24160705
DOI: 10.1146/annurev-pharmtox-011613-135921

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