Article
Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability.
Molecular psychiatry - 1 Jun 2024
Zhang Haibin, Zheng Qiuyang, Guo Tiantian, Zhang Shijun, Zheng Shuang, Wang Ruimin, Deng Qingfang, Yang Guowei, Zhang Shuo, Tang Linxin, Qi Qiuping, Zhu Lin, Zhang Xiu-Fang, Luo Hong, Zhang Xian, Sun Hao, Gao Yue, Zhang Hongfeng, Zhou Ying, Han Aidong, Zhang Chen-Song, Xu Huaxi, Wang Xin
Abstract excerpt
Astrocyte aerobic glycolysis provides vital trophic support for central nervous system neurons. However, whether and how astrocytic metabolic dysregulation contributes to neuronal dysfunction in intellectual disability (ID) remain unclear. Here, we demonstrate a causal role for an ID-associated SNX27 mutation (R198W) in cognitive deficits involving reshaping astrocytic metabolism. We generated SNX27R196W...
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