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Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry

2023-12-08

Abstract excerpt

Histone deacetylase inhibitors (HDIs) modulate β cell function in preclinical models of diabetes; however, the mechanisms underlying these beneficial effects have not been determined. In this study, we investigated the impact of the HDI sodium butyrate (NaB) on β cell function and calcium (Ca 2+ ) signaling using ex vivo and in vitro models of diabetes. Our results show that NaB significantly improved glucose-sti...

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Literature Corpus work: 18b19b4c-4392-52f8-b65e-057397e1ff0c
DOI: 10.1101/2023.12.06.570443

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Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium EntryDOI 10.1101/2023.12.06.570443Read

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