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Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases and Immunoproteasomal Activity

2020-11-19

Abstract excerpt

Pancreatic β-cell-specific clock knock-out mice develop β cell oxidative-stress and failure, as well as glucose-intolerance. How inflammatory stress affects the cellular clock is under-investigated. Real-time recording of Per2:luciferase reporter activity in murine and human pancreatic islets demonstrated that the proinflammatory cytokine Interleukin-1β (IL-1β) lengthened the circadian period....

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Literature Corpus work
afce77c5-2ebf-509c-84fd-a7bb5669808c
DOI
10.20944/preprints202011.0515.v1
Open publication

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Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases and Immunoproteasomal ActivityDOI 10.20944/preprints202011.0515.v1
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