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Circadian desynchronization desensitizes insulin-producing cells to cytokine-mediated transcriptomic remodeling and cell death: a novel beta-cell anti-apoptotic response to inflammation

2024-04-15

Abstract excerpt

Perturbation of the circadian clock is a risk factor for metabolic diseases. Beta-Cell specific clock disruption causes glucose intolerance in mice, associated with oxidative stress and secretory failure in beta-cells. Proinflammatory cytokines alter the expression of core-clock machinery in human and rodent beta-cells, but the molecular mechanisms and consequences for cell viability are unclear. We hypothesized t...

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Literature Corpus work
172e0b83-2838-52db-8664-3b5dbba0c77a
DOI
10.1101/2024.04.12.589193
Open publication

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Circadian desynchronization desensitizes insulin-producing cells to cytokine-mediated transcriptomic remodeling and cell death: a novel beta-cell anti-apoptotic response to inflammationDOI 10.1101/2024.04.12.589193
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