Article

Galectin-3 Impairs Calcium Transients and β-Cell Function

2024-01-09

Abstract excerpt

<title>Abstract</title> <p>In diabetes, macrophages and inflammation are increased in the islets, along with β-cell dysfunction. Here, we demonstrate that galectin-3 (Gal3), mainly produced and secreted by macrophages, is elevated in islets from both high-fat diet (HFD)-fed and diabetic <italic>db/db</italic> mice. Gal3 acutely reduces glucose-stimulated insulin secretion (GSIS) inβ-cell lines and primary islets...

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Literature Corpus work: f01b9c32-b617-5565-ba66-87f4a7b41d24
DOI: 10.21203/rs.3.rs-3834457/v1

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